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Signal Transduction |
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Signal transduction research aims to
elucidate the molecular mechanisms underlying the biological
responses to non-genotoxic environmental agents,
specifically: |
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1. |
To delineate signal transduction pathways and their effector components in various model systems;
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2. |
To study the molecular mechanisms associated with the
disruption of pathways, effectors, signal perception or
signal transmission as a consequence of exposure to
environmental agents; |
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3. |
To analyze how variations in genetic background affect
normal signal transduction pathways. The purpose of this
research is to study the signal transduction pathways and
molecular mechanisms used by toxic environmental
agents to exert their harmful action. Modification of gene
expression patterns by these agents interferes with the
normal control mechanisms that regulate the levels of
tissue-specific receptors and effector molecules, the
production of second messengers, and the
synthesis and activation of transcription
factors. Since components of the signal
transduction machinery are not only
genetically determined but are also
themselves under genetic regulation, it is
to be expected that genetic polymorphisms in
the genes coding for the components of
signal transduction pathways will be
extremely important in determining the outcome of
exposure. |
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Faculty performing research in this field:
Alvaro
Puga, Ying
Xia ,Jagjit
Yadav, Stuart
Baxter |
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