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The long-range goals
of our molecular toxicology research are to investigate the
mechanisms by which genotoxic and non-genotoxic
environmental agents are metabolized to toxic intermediates.
The aim is to determine how the genotoxic agents interact
with DNA and alter the chemical structure of DNA, how DNA
damage leads to mutations, and how cellular mutation
avoidance mechanisms (e.g., DNA repair and cell cycle
arrest) function to counteract mutagenesis, and focusing on
the role that individual differences in genetic makeup play
in determining the outcomes of exposure.
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1 |
understand how
differences in metabolism influence the potency and
target organ specificity of genotoxic agents;
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2 |
develop sensitive
biomarkers for exposure endpoints to use as a basis
for determining individual responses to exposure;
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3 |
understand molecular
mechanisms of each response; |
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4 |
determine how signal
transduction in DNA repair induced by toxic agents
affects outcome |
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5 |
understand how specific
gene polymorphisms affect genetic stability |
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Faculty performing research in this field:
Howard
Shertzer,
Michael
Borchers, Daniel
Nebert, Marian
Miller,
Mary Beth
Genter, Jagjit
Yadav |
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