| The
objectives of this research include: |
|
1. |
Identification within a species of genetic polymorphisms
associated with differences in response to environmental agents;
|
|
2. |
Elucidation of the molecular genetic basis of these polymorphisms;
|
|
3. |
Determination of the prevalence of different alleles in
human populations and the mode of inheritance through family
studies; |
|
4. |
Evaluation of the impact of a given polymorphism on human
health; and |
|
5. |
Clinical pharmacogenetics and pharmacogenomics. This research
increasingly has focused on the importance of "multiplex phenotypes"
(i.e. role of two or more genes involved in environmental
toxicity or cancer), as well as the closer integration with
genomics and the Human Genome Project.
|