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Our research objectives are to investigate the genetic
determinants controlling the response of the lung to
environmental agents. These objectives are to be met by the
following specific aims: |
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1. |
To examine the genetic determinants of complex respiratory
diseases including asthma and acute lung injury (neonatal
alveolar proteinosis and adult respiratory distress syndrome),
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2. |
To develop model systems of altered susceptibility to
environmental injury (e.g., gene targeted, cell-directed,
and conditional transgenesis in the mouse lung), and
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3. |
To examine developmental genomic programs that are evoked
during epithelial injury and repair (e.g., lung genes under
control of the mitogen- and stress-activated pathways).
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Faculty performing research in this field:
Michael
Borchers,
Daniel
Nebert |