Jagjit, Yadav Jagjit Yadav
138 Kettering
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University of Cincinnati, Cincinnati, OH, Postdoctoral, 1995-1998, Molecular Biology
Michigan St. University, E. Lansing, MI, Postdoctoral, 1991-1995, Microbial Physiology/ Genetics
Kurukshetra University, Kurukshetra, India, Ph.D., 1984, Microbiology
Kurukshetra University, Kurukshetra, India, M.Sc., 1978, Bacteriology
BNC University, Kurukshetra, India, B.Sc., 1976, Biology, Chemistry


1972-1976: University Merit awards at all stages of undergraduate education.
1976-1978: National Merit Fellowship awarded for M.S. program
1978: "Best Student" award in M.S. (Microbiology) program 1977-78
1979-1982: UNDP/FAO (UNO) fellowship awarded for Ph.D. Program.
1985: Natl. Biotechnology Board Fellowship for Advanced training in molecular biology.
1989: FAO (UNO) Fellowship for advanced studies in funal Molecular Biology (Visiting Scientist,Dept. of Biological Sci., Univ. of South Carolina, Columbia).
2006: Awarded UC-COM Dean’s merit award
2010-12: UC-COM DEH Director merit raise awards
2013: Recognition by the American Society for Microbiology (ASM), International Board on Global Engagement

1993-1994: Elected full member of the Sigma Xi: The Scientific Research Society
1991-Present: Member of the American Society for Microbiology (ASM)
1999-Present: Member of the American Association for the Advancement of Science (AAAS)
2003-Present: Mentor for Underrepresented Minority members of the American Society for Microbiology
2005: Member, NIEHS/NIH working group on molds and microbes in Katrina aftermath.
2007: Member, ACGIH Bioaerosols Committee
2007- 2013: Member, International Committee on Global Engagement, American Society for Microbiology.
2013: Full Member, Society of Toxicology (SOT)
2007-Present: Member, Editorial Booard, Clinical Medicine and Research
2009-Present: Member, Editorial Booard, Appl Environ Microbiology
2010-Present: Associate Editor, J. Integrated OMICs
2010-Present: Associate Editor, J. Molecular Biomarkers & Diagnostics
2008-Present: Associate Editor, BMC Genomics

Awarded 25 grants thus far from various federal (NIH/NIEHS, NIAID, NIOSH, DOJ) and non-federal (UAW, USCAR) agencies/sources, including 5 R01 awards.

Professional Experience

1978-1979: Microbiologist, Jagatjit Industries Ltd., Punjab, India.
1979 (Mar.-Aug.): Sr. Research Associate, National Dairy Res. Institute (NDRI),Karnal, Haryana, India.
1982- 1990: Scientist (Assistant Professor equiv.) in Microbiology , National Dairy Research Institute (Deemed University), Karnal, India [1982-1987: Scientist S-1; 1987-1990: Scientist S-1 senior grade].
1991-1995: Vst. Researcher, Dept. of Microbiology, Mich. St. Univ., East Lansing, MI.
1995-1998: Researcher/Postdoctoral, Dept of Molecular Genetics, Biochemistry & Microbiology, Univ. of Cincinnati, OH.
1998-2005: Assistant Professor, Dept. of Environ. Health (Mol. Toxicology), Univ. of Cincinnati, OH.
2005-2011: Associate Professor (tenured), Dept. of Environ. Health (Environ. Genetics & Molecular Toxicology), Univ. of Cincinnati, College of Medicine, OH.
2011-Present: Professor, Dept. of Environmental Health (Environ. Genetics & Molecular Toxicology Division), Univ. of Cincinnati, College of Medicine, OH.
2013-Present: Director, Center for Environmental Genetics Pilot Projects Program

Selected Publications

Selected from a list of over 125 Research articles, 5 Book chapters, 1 Book , and 4 US patents.

I. Cytochrome P450 research (functional genomics, structure-activity relationships)

Syed K., A. Porollo, D. Miller, and J.S. Yadav. 2013. A rational engineering of the fungal P450 monooxygenase CYP5136A3 to improve its oxidizing activity toward Polycyclic aromatic hydrocarbons. Protein Engg Design & Selection (PEDS) (in press) Jul 31. [Epub ahead of print]; [Highlighted on the “FACEPAGE” of the journal].

Syed K., Nelson D.R., Riley R., and J.S. Yadav. 2013. Genome-wide annotation and comparative genomics of cytochrome P450 monooxygenases (P450s) in the polypore species Bjerkandera adusta, Ganoderma sp. and Phlebia brevispora. Mycologia (in press) Aug 8 [Epub ahead of print].

Bhattacharya S.S., Syed K., Shan J, and J.S. Yadav. 2013. A novel biphasic process for sustainable biodegradation of benzo[a]pyrene in soil under nutrient-sufficient conditions by the white rot fungus Phanerochaete chrysosporium. J. Haz. Mat. (in press).

Syed K., A. Porollo, Y.W. Lam, P. Grimmett, and J.S. Yadav. 2013. A catalytically versatile fungal P450 monooxygenase (CYP63A2) from white rot fungus. Appl Environ Microbiol 79(8):2692-2702.
[Highlighted in the “SPOTLIGHT” of the journal, a feature in the journal highlighting 5 meritorious research articles in the upcoming issue that have been deemed of significant interest]

Floudas D, M. Binder, R. Riley, K. Barry, R.A. Blanchette, B. Henrissat, A.T. Martinez, R. Otilar, J.W. Spatafora, J.S. Yadav et al. 2012. The Paleozoic origin of enzymatic mechanisms for decay of lignin reconstructed using 31 fungal genomes. Science 336:1715-1719 (June 28th issue, 2012).

Syed K and JS Yadav. 2012. P450 monooxygenases (P450ome) of the model white rot fungus Phanerochaete chrysosporium. Crit. Rev. Microbiol. 38(4):339-63.

Fernandez-Fueyo E, FJ Ruiz-Dueñas, P Ferreira, D Floudas, D Hibbett, P Canessa, LF Larrondo, TY James, D Seelenfreund, S Lobos, R Polanco, M Tello, Y Honda ,T Watanabe, T Watanabe, J San Ryu, CP Kubicek, M Schmoll, J Gaskell, KE Hammel, FJ St. John, A Vanden Wymelenberg, G Sabat, SS BonDurant, K Syed , JS Yadav, et al. 2012. Comparative genomics of Ceriporiopsis subvermispora and Phanerochaete chrysosporium provide insight into selective ligninolysis mechanisms. Proc. Nat. Acad. Sci. US, 109(14):5458-63.

Suzuki H., J. MacDonald, K. Syed...........J.S. Yadav, I.V. Grigoriev, and E.R. Master. 2012. Comparative genomics of the white-rot fungi, Phanerochaete carnosa and P. chrysosporium, to elucidate the genetic basis of the distinct wood types they colonize. BMC Genomics 13:444 doi:10.1186/1471-2164-13-444

Syed K., Porollo, A., Lam, Y.W. and J. S. Yadav. 2011. A fungal P450 (CYP5136A3) capable of oxidizing polycyclic aromatic hydrocarbons and endocrine disrupting chemicals: Role of Trp129 and Leu324. PLOS One 6(12):e28286

Syed K., C. Kattamuri, T. B. Thompson, and J. S. Yadav. 2011. Cytochrome b5 reductase- Cytochrome b5 as an active P450 redox enzyme system in Phanerochaete chrysosporium: Atypical properties and in vivo evidence of electron transfer capability to CYP63A2. Arch. Biochem. Biophys. 509(1):26-32.

Syed, K, H. Doddapaneni, V. Subramanian, Y. Wai Lam, and J. S. Yadav. 2010. Genome-to-function characterization of novel fungal P450 monooxygenases oxidizing polycyclic aromatic hydrocarbons (PAHs). Biochem. Biophys. Res. Commun. 399(4):492-497.

Martinez D, et al. 2009. Genome, transcriptome, and secretome analysis of the fungus Postia placenta supports unique mechanisms of lignocellulose conversion. PNAS 106(6):1954-1959.

Subramanian, V. and J.S. Yadav. 2008. Regulation and heterologous expression of P450 enzyme system components of the white rot fungus Phanerochaete chrysosporium. Enzym. Microbial technol. 43(2):205-213.

Yadav JS, Doddapaneni H, Subramanian V. 2006. P450ome of the white rot fungus Phanerochaete chrysosporium: structure, evolution and regulation of expression of genomic P450 clusters. Biochem Soc Trans. 2006 Dec;34(Pt 6):1165-9.

Doddapaneni, H. and J.S. Yadav. 2005. Microarray-based expression profiling of P450 monooxygenases and regulatory proteins for signal transduction pathways in the white rot fungus Phanerochaete chrysosporium. Mol. Genet. Genomics 274:454-466.

Doddapaneni, H, Chakraborty, R., and J.S. Yadav. 2005. Genome-wide structural and evolutionary analysis of the P450 monooxygenase genes (P450ome) in the white-rot fungus Phanerochaete chrysosporium: Evidence for gene duplications and extensive gene clustering. BMC Genomics. 6:92, p1-24.

Doddapaneni, H.and J.S. Yadav. 2004. Differential regulation and xenobiotic induction of tandem P450 monooxygenase genes pc-1 (CYP63A1) and pc-2 (CYP63A2) in the white rot fungus Phanerochaete chrysosporium, Appl. Microbiol Biotechnol. 65: 559-565.

Yadav, J.S., M. B. Soellner, J.C. Loper, and P.K. Mishra. 2003. Tandem Cytochrome P450 monooxygenase genes and splice variants in the white rot fungus Phanerochaete chrysosporium: cloning, sequence analysis and regulation of differential expression. Fungal Genetics & Biol. 38(1): 10-21.

Yadav, J.S. and J.C. Loper. 2000. Cytochrome P450 oxidoreductase gene and its differentially terminated cDNAs from the white rot fungus Phnaerochaete chrysosporium. Current Genetics, 37:65-73.

Yadav, J. S. and J. C. Loper, 1999. Multiple P450alk (cytochrome P450 alkane hydroxylase) genes from the halotolerant yeast Debaryomyces hansenii. GENE 226:139-146.

II. Host lung–Pathogen/Toxicant interactions (mycobacteria, select agents, mycotoxins)

Yadav, J.S., Pradhan S., Kapoor R., Bangar H., Burzynski B.B., Prows D.R., and L. Levin. 2011. Multigenic control and sex bias in host susceptibility to spore-induced pulmonary anthrax in mice. Infection and Immunity 79(8):3204-3215.

Yadav, J.S and R. Kapoor. 2012. Bloodborne pathogens in the workplace. In: Patty’s Toxicology 6th Edition, Chapter 93, John Wiley & Sons, Inc.

Yadav, J.S and R. Kapoor. 2012. Tuberculosis and other mycobacteria. In: Patty’s Toxicology 6th Edition, Chapter 94, John Wiley & Sons, Inc..

Gupta, M., V. Subramanian, and J.S. Yadav. 2009. Immunoproteomic identification of secretory and subcellular antigenic proteins and functional evaluation of the secretome fraction of Mycobacterium immunogenum, a newly recognized species of the M. chelonae-M. abscessus group. J. Proteome Res. 8:2319-2330.

Wang H, Yadav JS. 2007. Global gene expression changes underlying Stachybotrys chartarum toxin-induced apoptosis in murine alveolar macrophages: Evidence of multiple signal transduction pathways. Apoptosis. 12:535-548.

Wang, H. and J.S. Yadav. 2006. DNA damage, redox changes, and associated signaling events underlying the apoptosis and cytotoxicity in murine alveolar macrophage cell line MH-S by methanol-extracted Stachybotrys chartarum toxins. Toxicol Appl Pharmacol. 214:297-308.

III. Antimicrobial resistance (mycobacteria)

Selvaraju, S., I.U.H. Khan, and J.S. Yadav. 2011. Susceptibility of Mycobacterium immunogenum and Pseudomonas fluorescens to Formaldehyde and Non-Formaldehyde Biocides in Semi-Synthetic Metalworking Fluids. Int. J. Mol Sci. 12, 725-741.

Kapoor, R. and J.S. Yadav. 2010. Development of a rapid ATP bioluminescence assay for biocidal susceptibility testing in rapidly growing Mycobacteria. J. Clin. Microbiol. 48(10):3725-8.

Selvaraju, S., I.U.H. Khan, and J.S. Yadav. 2008. Differential biocide susceptibility of the multiple genotypes of Mycobacterium immunogenum. J. Ind. Microbiol. Biotechnol. 35:197-203.

Selvaraju, S. B., I. U. H. Khan, and J. S. Yadav. 2005. Biocidal activity of formaldehyde and non-formaldehyde type biocides on Mycobacterrium immunogenum and Pseudomonas fluorescens as pure and mixed suspensions in simulated synthetic Metalworking Fluid (MWF). Appl. Environ. Microbiol. 71(1):542-546.

IV. Molecular diagnostics (mycobacteria; other respiratory pathogens)

Yadav, JS, Doddapaneni H, Selvaraju SB, and Chakraborty R. Novel genomic markers and a multi-locus genomic assay specific for Bacillus anthracis. Appl. Environ. Microbiol. (manuscript).

Das Debarun, Marwan Al-Rjoub, Jagjit S. Yadav, and Rupak K. Banerjee. 2012. Capture of magnetic microspheres in electrokinetic flow for application in lab-on-chip devices. Proceedings of the ASME 2012 Summer Bioengineering Conference SBC2012 , June 20-23, Farjardo, Puerto Rico, USA. SBC2012-80893, p1-2.

Kapoor, R. and J.S. Yadav. 2011. Expanding the mycobacterial diversity in metalworking fluids: evidence of colonization by Mycobacterium abscessus. FEMS Microbiol. Ecol. 79(2):392-399.

Kapoor R and J. S. Yadav. 2009. Development of a species-specific colorimetric-PCR assay for detection and species differentiation of Mycobacterium immunogenum and M. chelonae and its comparison with quantitative real-time PCR. Mol. Cell. Probes 23:75-82.

Selvaraju, S.B. R. Kapoor, and J.S. Yadav. 2008. Peptide Nucleic Acid-Fluorescence in-situ hybridization (PNA-FISH) assay for specific detection of Mycobacterium immunogenum and DNA-FISH assay for analysis of pseudomonads in MWF and sputum. Mol. Cell. Probes 22:273-280.

Khan, I. U. H., S. B. Selvaraju and J. S. Yadav. 2005a. Multiple genotypes of Mycobacterium immunogenum and Mycobacterium chelonae from MWF. FEMS Microbiol Ecol.54:329-338.

Khan, I. U. H., S. B. Selvaraju, and J. S. Yadav. 2005b. Species differentiation for Mycobacterium chelonae complex based on 16S-23S Ribosomal DNA internal transcribed spacer (ITS) sequencing and ITS PCR-restriction analysis (ITSPRA). J. Clin. Microbiol. 43(9): 4466-4472.

Khan, I.U.H. and J.S. Yadav. 2004. Development of a single-tube cell lysis-based genus-specific PCR method for rapid detection of mycobacteria: optimization of cell lysis, PCR primers and conditions. J. Clinical Microbiol. . 42: 453-457.

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