Alexey, Porollo Alexey Porollo
316 Kettering
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eLab of Aleksey Porollo

Research Description:

Dr. Porollo’s research is focused on the development of new prediction methods and analytical tools in structural bioinformatics. He is particularly interested in protein structure prediction (co-author of the methods SABLE and MINNOU), identification and analysis of protein-protein, as well as protein-ligand, interactions (primary author of SPPIDER and POLYVIEW) in the context of environmental stimuli and insults. Applications of the computational approaches, with high medical significance, include structural and functional characterization of proteins, identification of alternative drug targets, virtual drug screening, and evaluation of potential toxic effects as part of gene-environment interaction.

Dr. Porollo’s research includes a number of interdisciplinary, both intra- and interdepartmental, projects. Collaborative efforts embrace the following studies: (i) identification of structural factors influencing enzymatic activity and substrates recognition of the PAH-oxidizing fungal cytochrome P450 (CYP5136A3); (ii) analysis of metalloproteome of human macrophages involved in defense against fungal infection; (iii) analysis of the new cytoprotective function of Gap junction alpha-1 protein (Connexin-43); and (iv) investigation of the role of sequestosome-1 (p62) in oncogenesis. In addition, Dr. Porollo leads the project on discovery of new drugs for anti-Pneumocystis therapy, utilizing large-scale virtual screening and novel targets in the Pneumocystis fungal pathogen.

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